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论著:奥扎格雷钠联合依达拉奉治疗急性脑梗死患者的疗效
Clinical Effect of Sodium Ozagrel Combined with Edaravone in Treating Acute Brain Infarction
杜文华 何琳琳 李景春
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作者单位:北京市昌平区华一医院神经内科
中文关键字:急性脑梗死;奥扎格雷钠;依达拉奉;高敏C反应蛋白
英文关键字:Acute brain infarction; Sodium ozagrel; Edaravone; High sensitive C reaction protein
中文摘要:目的:观察奥扎格雷钠注射液联合依达拉奉治疗急性脑梗死患者的疗效。方法:将130例急性脑梗死患者随机分为两组:奥扎格雷钠组(对照组,n=65),奥扎格雷钠联合依达拉奉治疗组(治疗组,n=65),共治疗2周。治疗前和治疗2周后分别采用美国国立卫生研究所脑卒中评分(United States National Institute of Health Stroke Scale, NIHSS)评定患者神经功能,同时采用免疫浊度法检测高敏C反应蛋白(high sensitivity C reactive protein, hs CRP)含量。结果:治疗2周后两组神经功能缺损评分较治疗前明显改善,且治疗组显著优于对照组(P<0.01);治疗组总有效率为92.3%,显著高于对照组的81.5%(P<0.01);治疗前两组hs CRP水平差异无统计学意义(P>0.05),治疗后两组hs CRP均降低,而且治疗组hs CRP水平显著低于对照组(P<0.01)。结论:奥扎格雷钠注射液联合依达拉奉治疗急性脑梗死可显著提高显效率,改善神经功能,并且降低患者hs CRP水平。
英文摘要:Objective: To observe the clinical effect of sodium ozagrel combined with edaravone in treating acute brain infarction. Methods: A total of 130 patients with cerebral infarction were randomly divided into sodium ozagrel group (control group n=65) and sodium ozagrel combined with edaravone group (treatment group, n=65). The neurologic impairment degree was evaluated by United States National Institute of Health Stroke Scale (NIHSS) before the treatment and 2 weeks after treatment. The levels of high sensitive C reaction protein(hs CRP) were measured by immune turbidity method. Results: The efficient rate of teatement group (92.3%) was significantly higher than that of the control group (81.5%),P<0.01. The level of hs CRP in the treatment group was significantly lower than that of the control group after 14 days of treatment (P<0.01).Conclusions: Sodium ozagrel combined with edaravone can significantly improve neurological function and decrease the levels of hs CRP in patients with cerebral infarction.
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