网络编辑平台

编辑出版

《中国临床医学》编辑部

  地址:上海市枫林路179号18号楼501室

  邮编:200032

  电话:021-60267570

  邮箱:(1)zglcyx@126.com; (2)zglcyxfb@126.com

作者园地

在线调查

您喜欢的投稿方式调查


相关下载

您所在位置:首页->过刊浏览->第19卷第4期


论著:甲状腺毒症患者甲状腺上动脉收缩期平均峰流速与摄碘率相关分析
Relationship between Mean Peak Systolic Velocity of the Superior Thyroid Artery and Radioactive Iodine Uptake in Patients with Thyrotoxicosis
赵晓龙 陈立立 王涌 朱汇庆 何敏 鹿斌 周丽诺 李益明 胡仁明 刘红
点击:1483次 下载:0次
作者单位:复旦大学附属华山医院内分泌代谢科
中文关键字:甲状腺毒症;超声检查;甲状腺上动脉收缩期流速峰值;Graves病;破坏性甲状腺炎
英文关键字:Thyrotoxicosis; Ultrasonography; Peak systolic velocity of superior thyroid artery; Graves’ disease; Destructive thyroiditis
中文摘要:目的:探讨未经治疗的甲状腺毒症患者甲状腺上动脉平均峰值流速(mean STA PSV)与摄碘率的相关性,评价STA PSV在甲状腺毒症病因鉴别中的价值。方法:本研究为前瞻性临床研究,共入选未经治疗的甲状腺毒症患者145例,包括Graves病组(n=96)和甲状腺炎组(n=49),在1周内测定其摄碘率、甲状腺功能与STA PSV。采用两独立样本t检验比较Graves病组与甲状腺炎组患者摄碘率、甲状腺功能与STA PSV的差异,用线性回归分析探讨3 h及24 h摄碘率与STA PSV之间的相关性,用受试者工作曲线(ROC)评价STA PSV对于Graves病和甲状腺炎的鉴别价值。结果:Graves病组的STA PSV显著高于甲状腺炎组[(75.51±2.80) cm/s比(33.16±2.33) cm/s,P<0.05];平均STA PSV与3 h摄碘率(r=0.532,P<0.001)以及24 h摄碘率(r=0.471,P<0.001)均呈显著正相关。平均STA PSV鉴别Graves病与破坏性甲状腺炎的ROC曲线下面积为0.825,最佳切点为45.3 cm/s,敏感性为80.4%,特异性为81.4%。结论:平均STA PSV与甲状腺摄碘率具有良好的相关性。结论:超声下甲状腺上动脉峰流速测定是一种可靠便捷的方法,可部分替代摄碘率用于甲状腺毒症的病因鉴别。
英文摘要:Objective: To explore the relationship between mean peak systolic velocity of the superior thyroid artery (STA PSV) and radioactive iodine uptake (RAIU) in patients with thyrotoxicosis. Methods: This study was a prospective clinical study in Chinese population. In all, 145 patients with untreated thyrotoxicosis were recruited. All participants underwent examination of thyroid function, radioactive iodine uptake (RAIU) and ultrasonography. Mean STA PSV was measured by ultrasonography. RAIU test identified 96 patients with Graves’ disease (GD) and 49 patients with destructive thyroiditis (DT). Student’s t test was used to compare differences between groups. Results: The mean STA PSV was significantly higher in GD group than in DT group [(75.51±2.80) cm/s vs. (33.16±2.33) cm/s, P<0.05]. The mean STA PSV correlated positively and significantly with 3h RAIU (r=0.532 , P<0.001), as well as with 24h RAIU (r=0.471, P<0.001). The area under the ROC curve of mean STA PSV in the differential diagnosis of GD and DT was 0.825. The optimal cutoff point of mean STA PSV was 45.3 cm/s, with a sensitivity of 80.4% and aspecificity of 81.4%. Conclusions: Detection of mean STA PSV by ultrasonography is concordant with RAIU and is an eligible method for the differential diagnosis of thyrotoxicosis.
读者评论

      读者ID: 密码:   
我要评论:
主办单位:复旦大学附属中山医院
联系地址:上海市枫林路179号18号楼501室 邮编:200032
联系电话:021-60267570 E-Mail:(1)zglcyx@126.com; (2)zglcyxfb@126.com
版权所有©2009-2010 《中国临床医学》杂志编辑部 沪ICP备1103249号
本系统由北京菲斯特诺科技有限公司设计开发
您是本站第1269991名访问者