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论著:2型糖尿病患者血脂水平与糖化血红蛋白、胰岛素抵抗及胰岛β细胞功能的关系
Relationships among the Levels of Blood Lipid and Glycosylated Hemoglobin,Insulin Resistance and β Cell Function in Patients with Type 2 Diabetes
何双涛 刘军 周连华
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作者单位:复旦大学附属上海市第五人民医院内分泌科
中文关键字:血脂;糖化血红蛋白;胰岛素抵抗;胰岛β细胞功能
英文关键字:Blood lipid; Glycosylated hemoglobin; Insulin resistance; β cell function
中文摘要:目的:探讨2型糖尿病患者的血脂水平与其糖化血红蛋白水平、胰岛素抵抗情况及胰岛β细胞功能的关系。方法:入选2型糖尿病患者136例,分别以糖化血红蛋白10.0%、胰岛素抵抗指数2.8以及胰岛功能指数20为界值将其分为高糖化血红蛋白组(HH组,n=76)、低糖化血红蛋白组(LH组,n=60);胰岛素重抵抗组(IR组,n=65)、胰岛素轻抵抗组(SR组,n=71);胰岛β细胞功能轻减退组(BN组,n=74)和胰岛β细胞功能重减退组(BW组,n=62),分析各组的血脂水平。结果:HH组和LH组的三酰甘油(TG)和高密度脂蛋白(HDL)的水平均无显著差异(P>0.05),HH组的总胆固醇(TC)和低密度脂蛋白(LDL)的水平显著高于LH组(P<0.05);IR组的TG水平显著高于SR组(P<0.05);BW组的HDL水平显著高于BN组(P<0.05)。结论:2型糖尿病患者血糖越高、胰岛素抵抗越严重、胰岛β细胞功能越差,血脂紊乱越严重。
英文摘要:Objective: To investigate the relationship between the level of blood lipid and glycosylated hemoglobin, insulin resistance,β cell function in patients with type 2 diabetes. Methods: A total of 136 hospitalized patients with type 2 diabetes have been enrolled in the trial.They were divided into high glycosylated hemoglobin group (Group HH) and low glycosylated hemoglobin group (Group LH) with the cutoff point of 10.0%,insulin high resistance group (Group IR) and insulin low risistance (Group SR) with the cutoff point of 2.8, low hypo β cell function group (Group BN) and high hypo β cell function group (Group BW) with the cutoff point of 20.The levels of blood lipid between each pair of groups were compared respectively. Results: The levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL) Group HH were significantly higher than those in Group LH (P<0.05). The level of triglyceride (TG) in Group IR was significantly higher than that in the Droup SR (P<0.05). The level of high density lipoprotein cholesterol (HDL) in Group BW was significantly higher than that in Group BN (P<0.05). Conclusions: Poor glucose control, highly insulin resistance and low β cell function were correlated with the disorder of blood lipid in patients with type 2 diabetes.
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