网络编辑平台

编辑出版

《中国临床医学》编辑部

  地址:上海市枫林路179号18号楼501室

  邮编:200032

  电话:021-60267570

  邮箱:(1)zglcyx@126.com; (2)zglcyxfb@126.com

作者园地

在线调查

您喜欢的投稿方式调查


相关下载

您所在位置:首页->过刊浏览->第19卷第4期


论著:冠状动脉介入术围术期血小板膜糖蛋白表达水平的变化及其临床意义
Changes in Plasma Levels of Platelet Glycoprotein in Patients Undergoing Percutaneous Coronary Intervention
姚建华 王豪 陈德 许嘉鸿 马瑾 王蕊 王渊铭 陈楠楠 张书富
点击:1417次 下载:0次
作者单位:同济大学医学院
中文关键字:血小板膜糖蛋白Ⅱb/Ⅲa ;血小板膜糖蛋白Ⅵ;急性冠状动脉综合征
英文关键字:Platelet glycoprotein Ⅱb/Ⅲa;Platelet glycoprotein Ⅵ;Acute coronary syndrome
中文摘要:目的:动态观察急性冠状动脉综合征(acute coronary syndrome,ACS)患者介入术前、术后血浆中血小板膜糖蛋白Ⅱb/Ⅲa(platelet glycoprotein Ⅱb/Ⅲa,GPⅡb/Ⅲa)、血小板膜糖蛋白Ⅵ(platelet glycoprotein Ⅵ,GPⅥ) 浓度的变化,探讨其临床意义。方法:将94例行冠状动脉造影的患者,根据其临床表现、心电图、血生化检查和冠状动脉造影结果分为肌钙蛋白T(troponin T,TnT)阳性ACS组(TnT+ ACS 组,n=35) 、TnT 阴性ACS组(TnT ACS组,n=38)和冠状动脉正常组(n=21)。采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)测定 3 组患者在冠状动脉介入术前即刻、术后6 h 和术后24 h时间点的 GPⅡb/Ⅲa和GP Ⅵ的浓度。结果:TnT+ ACS 组与 TnT ACS组和冠状动脉正常组比较,各个时间点的 GPⅡb/Ⅲa 浓度均显著升高(P<0.05)。TnT ACS 组中术后6 h的GPⅡb/Ⅲa的浓度显著高于术前和术后24 h(P<0.05)。TnT+ ACS 组术前、术后6 h 及术后24 h 的 GPⅥ 浓度均比冠状动脉正常组显著升高(P<0.05)。TnT+ ACS 组术后6 h 及术后24 h 的 GPⅥ 浓度较术前显著升高(P<0.05)。结论:动态检测血浆中 GPⅡb/Ⅲa、GPⅥ 浓度的变化能反映 ACS 患者体内血小板的活化情况,GPⅡb/Ⅲa和GPⅥ 的检测对冠状动脉介入术后血栓形成的风险评估有一定临床意义。
英文摘要:Objective: To study the changes of platelet glycoprotein Ⅱb/Ⅲa(GPⅡb/Ⅲa) and platelet glycoprotein Ⅵ (GPⅥ) levels in the plasma from patients with acute coronary syndrome (ACS). Methods: A total of 94 patients undergoing coronary angiography were enrolled. Based on clinical symptoms and results of blood biochemical examination, electrocardiogram and coronary angiography, patients were classified into three groups: troponin T (TnT)+ ACS group(n=35), TnT ACS group(n=38) and non coronary disease group(n=21). Plasma levels of GPⅡb/Ⅲa and GPⅥ were measured by enzyme linked immunosorbent assay (ELISA) before percutaneous coronary intervention(PCI) surgery, as well as 6 hours and 24 hours after PCI surgery. Results: The levels of GPⅡb/Ⅲa were significantly higher in TnT+ ACS group at all three time points compared with TnT ACS group and non coronary disease group (P<0.05). In TnT ACS group, significantly higher level of GPⅡb/Ⅲa was found at the time of 6 h after PCI compared with before surgery and 24 h after PCI(P<0.05). The levels of GPⅥ were significantly higher at all three time points in TnT+ ACS group compared with non coronary disease group(P<0.05), and the levels of GPⅥ in TnT+ACS group at the time of 6 hours and 24 hours after surgery were significantly higher than before surgery (P<0.05). Conclusions: Measurement of GPⅡb/Ⅲa and GPⅥ is a valuable tool to identify the patients with high risks for coronary thrombosis.
读者评论

      读者ID: 密码:   
我要评论:
主办单位:复旦大学附属中山医院
联系地址:上海市枫林路179号18号楼501室 邮编:200032
联系电话:021-60267570 E-Mail:(1)zglcyx@126.com; (2)zglcyxfb@126.com
版权所有©2009-2010 《中国临床医学》杂志编辑部 沪ICP备1103249号
本系统由北京菲斯特诺科技有限公司设计开发
您是本站第1269991名访问者