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论著:活性氧物质和超氧化物歧化酶与稽留流产的关系
Reactive Oxygen Species and Superoxide Dismutase Were Correlated with Missed Abortion
朱丽均 陈亚萍 陈炳锦 梅小会
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作者单位:复旦大学附属上海市第五人民医院妇产科
中文关键字:活性氧物质;超氧化物歧化酶;稽留流产;流式细胞仪;化学发光分析法;绒毛
英文关键字:Reactive oxygen species; Superoxide dismutase; Missed abortion; Flow cytometry; Chemiluminometry; Villi
中文摘要:目的:探讨绒毛组织中活性氧物质(reactive oxygen species, ROS)和超氧化物歧化酶(superoxide dismutase, SOD)与稽留流产的关系。方法:选取稽留流产患者20 例作为研究组,同时选取正常早孕要求流产者20 例作为对照组。研究组胚胎稽留宫内时间小于4周。采用流式细胞仪和化学发光分析法检测所有患者绒毛组织中ROS和SOD的水平。结果:与正常早孕女性相比,稽留流产患者绒毛组织中ROS水平显著增高(P<0.05),SOD水平显著降低(P<0.05)。结论:绒毛组织中ROS和SOD的平衡失调可能是导致稽留流产发生的重要因素。
英文摘要:Objective: To study whether reactive oxygen species(ROS) and superoxide dismutase(SOD) in placental villous tissue were related with missed abortion. Methods: Twenty patients with missed abortion (study group) and twenty early pregnant women undergoing abortion surgery (control group) were enrolled in this study. In patients with missed abortion the time embryos stayed in uterus after they died was less than four weeks. Fluorescent staining method and chemiluminometry were used to detect the levels of ROS and SOD in placental villous tissue. Results: The level of ROS in the study group was significantly higher than that in the control group ( P< 0.05), while the level of SOD in the study group was significantly lower than that in the control group ( P< 0.05). Conclusions: The imbalance of ROS and SOD in placental villous tissue may be an important cause of missed abortion.
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