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论著:ghrelin在结直肠癌中的表达水平及其意义
Expression of Ghrelin in Colorectal Carcinoma and Its Clinical Significance
田培营 卜淑蕊 樊晓明 周皓
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作者单位:复旦大学附属金山医院消化科
中文关键字:结直肠癌;ghrelin;分化
英文关键字:Colorectal carcinoma;Ghrelin; Differentiation
中文摘要:目的:探讨ghrelin在结直肠癌中的表达水平及意义。方法:选取40例不同分期结直肠癌患者(研究组)以及同期经电子肠镜检查排除结直肠癌的40例体检者(健康对照组),收集每个研究对象的血清和结直肠组织标本,采用酶联免疫吸附试验(enzyme linked immunosorbant assay, ELISA)检测血清和结直肠组织中ghrelin的表达水平。结果:研究组血清ghrelin表达水平与健康对照组之间无显著差异;不同Duke分期(A期、B期、C期、D期)的结直肠癌患者的血清中的ghrelin表达水平无显著差异;结直肠癌组织中的ghrelin水平与其组织分化程度呈负相关,分化程度低的结直肠癌组织中ghrelin表达水平高。结论:血清中ghrelin水平与结直肠癌发生无相关性,但结直肠癌患者癌组织中ghrelin表达水平与肿瘤分化程度呈负相关。
英文摘要:Objective: To study the levels of ghrelin in the serum and carcinoma tissues from colorectal carcinoma patients. Methods: A total of 40 patients with colorectal carcinoma at different stages have been enrolled (study group). At the same time, 40 people who were confirmed by electronic colonoscope not suffering from colorectal carcinoma have also been enrolled (control group). The levels of ghrelin in the serum and tissues were detected by enzyme linked immunosorbant assay (ELISA). Results: The level of serum ghrelin had no significant difference between the study group and the control group, or among patients at different stages(Duke A, B, C and D). The ghrelin level in colorectal carcinoma tissues had negative correlation with the degree of tumor differentiation. Conclusions: The level of ghrelin in the serum has no correlation with the development of colorectal carcinoma, but the ghrelin level in the carcinoma tissues has negative correlation with the degree of differentiation in colorectal carcinoma.
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