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论著:褪黑素对肺不张时多形核白细胞肺内聚集的抑制作用
Inhibition Effect of Melatonin on Polymorphonuclear Leukocytes Aggregation in Lung During Atelectasis
钟鸣 诸杜明 薛张纲
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作者单位:复旦大学附属中山医院麻醉科
中文关键字:褪黑素;肺不张;多形核白细胞
英文关键字:Melatonin; Atelectasis; Polymorphonuclear leukocytes
中文摘要:目的:探讨褪黑素对肺不张时多形核白细胞(polymorphonuclear leukocytes,PMNs)肺内聚集的抑制作用及其可能的机制。方法:将40只实验大鼠随机分成4组,每组10只,分别为对照组(C组)、褪黑素对照组(M组)、肺不张组( AC组)和褪黑素肺不张组( AC+M组)。所有大鼠右侧卧位切开胸腔,AC组和AC+M组游离左主支气管并用丝线结扎造成肺不张。手术结束后各组分别给予乙醇或褪黑素,24 h后取大鼠左侧肺组织标本检测。结果:AC组与AC+M组相比,PaCO2较高[(50±4.24) mmHg 比 (30±8.9) mmHg,P<0.01],PaO2较低[(45.9±13.1) mmHg 比(83.3±10.8) mmHg,P<0.01]。AC+M组肺组织IL 8浓度显著低于AC组[(53.58±18.1) pg/mL 比 (87.33±29.1) pg/mL,P<0.01],HE染色肺组织计数10个视野的PMNs总数AC+M组显著低于AC组[(216.3±27.14) 比(452.1±75.31),P<0.01]。结论:褪黑素能够抑制肺不张时期PMNs在肺组织内的聚集。
英文摘要:Objective: To investigate the inhibition effect of melatonin on polymorphonuclear leukocytes(PMNs) aggregation in lung during atelectasis. Methods:A total of 40 wistar rats were randomized to four groups:control group(Group C),melatonin group(Group M),atelectasis group(Group AC) and melatonin combined with atelectasis group(Group AC+M). Left thoractomy were performed in all rats,and left main bronchus of rats in Group AC and Group AC+M were ligated with silk. After surgery all rats were treated with melatonin and ethanol respectively, and left lung tissues were taken for measurement. Results: Compared with Group AC+M ,Group AC had higher PaCO2 [(50±4.24) mmHg vs. (30±8.9) mmHg,P<0.01]and lower PaO2[(45.9±13.1) mmHg vs. (83.3±10.8) mmHg,P<0.01].There was a significant difference in concentration of lung tissue IL 8 between Group AC and Group AC+M[(53.58±18.1) pg/mL vs. (87.33±29.1) pg/mL,P<0.01].PMNs counts of lung HE staining in Group AC+M was lower than that in Group AC[(216.3±27.14)/10HP vs. (452.1±75.31)/10HP, P<0.01]. Conclusions: Melatonin could inhibit PMNs aggregation in lungs during atelectasis.
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