网络编辑平台

编辑出版

《中国临床医学》编辑部

  地址:上海市枫林路179号18号楼501室

  邮编:200032

  电话:021-60267570

  邮箱:(1)zglcyx@126.com; (2)zglcyxfb@126.com

作者园地

在线调查

您喜欢的投稿方式调查


相关下载

您所在位置:首页->过刊浏览->第19卷第3期


论著:严重创伤患者血清中IL 6、IL 8和TNF α的动态变化及其临床意义
Dynamic Changes of Serum IL 6 , IL 8 and TNF α Levels in Patients with Severe Trauma
刘畅 鲍小荣 申捷
点击:1214次 下载:0次
作者单位:复旦大学附属金山医院
中文关键字:创伤;白细胞介素6;白细胞介素8;肿瘤坏死因子α
英文关键字:Trauma; Interleukin 6; Interleukin 8; Tumor necrosis factor α
中文摘要:目的:观察严重创伤后血清中白细胞介素 6(IL 6)、白细胞介素 8(IL 8)及肿瘤坏死因子 α(TNF α)的动态变化,探讨其临床意义。方法:45例严重创伤患者入选创伤组,分别在入院的第1、第3、第5、第10、第15天检测其血清TNF α、IL 6和IL 8的水平。20名健康体检者为对照组。将检测结果进行统计学分析。结果:与对照组比较,创伤组IL 6在损伤后第1天即升高,第3~5天达到高峰后开始逐渐下降;IL 8在损伤后第1天即升高,第3~5天达到高峰后开始逐渐下降;TNF α在损伤后第1天即升高,随后即逐渐下降直至恢复到基础水平。结论:动态观察严重创伤患者血清中细胞因子水平的变化有助于病情的评估。
英文摘要:Objective: To study the dynamic changes of serum interleukin 6 (IL 6), interleukin 8 (IL 8) and tumor necrosis factor (TNF α) in patients with severe trauma. Methods:Forty five patients with severe trauma were included(trauma group). Twenty healthy volunteers have also been enrolled(control group).Levels of IL 6,IL 8,and TNF α were detected on the 1st,3rd,5th,10th and 15th day after admission. Results: The serum levels of IL 6,IL 8 and TNF α in patients with severe trauma on the 1st day were significantly higher than those in the control group. Serum levels of IL 6 and IL 8 reached the peak after 3 to 5 days and then decreased gradually.Level of TNF α in creased at the 1st day and then decreased and gradually went back to normal level. Conclusions: Observation of the dynamic changes of serum cytokines in patients with severe trauma would contribute to the evaluation of the patient's condition.
读者评论

      读者ID: 密码:   
我要评论:
主办单位:复旦大学附属中山医院
联系地址:上海市枫林路179号18号楼501室 邮编:200032
联系电话:021-60267570 E-Mail:(1)zglcyx@126.com; (2)zglcyxfb@126.com
版权所有©2009-2010 《中国临床医学》杂志编辑部 沪ICP备1103249号
本系统由北京菲斯特诺科技有限公司设计开发
您是本站第1269992名访问者