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论著:转化生长因子β1 509基因多态性与绝经后2型糖尿病患者骨密度的关系
Transforming Growth Factor β1 509 Polymorphism is Associated with Bone Mineral Density in Postmenopausal Patients with Type 2 Diabetes Mellitus
陈珂 王博 张秀珍
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作者单位:上海曲阳医院内分泌科
中文关键字:骨密度;转化生长因子 β1;基因多态性;2型糖尿病;骨质疏松症
英文关键字:Bone density; Transforming growth factor beta 1; Gene polymorphism; Type 2 diabetes; Osteoporosis
中文摘要:目的:研究转化生长因子 β1 509(transforming growth factor β1 509, TGF β1 509)基因多态性各等位基因及基因型在绝经后女性2型糖尿病(type 2 diabetes mellitus,T2DM)患者中的分布频率,探讨其基因型及分布频率与骨质疏松症(osteoporosis, OP)的相关性。方法:上海地区汉族绝经女性患者共282例,其中OP患者105例(OP组),T2DM患者骨量正常患者90例(T2DM组),T2DM并发OP患者87例(T2DM 并发OP组);另取健康绝经女性82例作为对照 (对照组)。检测TGF β1 509基因多态性、第2~4腰椎(L2 4)骨密度(bone mineral density,BMD),同时检测血浆糖化血红蛋白A1c(hemoglobin A1c,HbA1c)。比较各临床指标与TGF β1 509基因型的相关性。结果:OP组、T2DM组、 T2DM 并发OP组和对照组TGF β1 509相比,等位基因型C、T的分布均无显著差异。合并OP组(OP组+T2DM并发OP组)和非OP组(T2DM组+对照组)TGF β1 509等位基因型C、T的分布频率比较有显著差异(P=0.015)。CC基因型、CT基因型、TT基因型比较,其HbA1c差异无统计学意义。结论:TGF β1 509等位基因型T可能是OP的易感基因,T2DM患者TGF β1 509基因型与HbA1c无相关性。
英文摘要:Objective: To explore the distribution of polymorphism of transforming growth factor beta1 (TGF β1) gene in shanghai post menopausal women with type 2 diabetes mellitus (T2DM), and to investigate the relationship between TGF β1 genotypes and osteoporosis(OP). Methods:A total of 282 unrelated post menopausal women of Han nationality in Shanghai region were recruited and divided into three groups. They were OP group (Group OP n=105), T2DM group (Group T2DM, n=90) and T2DM+OP group (Group T2DM+OP n=87). Another 82 healthy post menopausal women of Han nationality in Shanghai region were also enrolled (Group control n=82). TGF β1 509 gene polymorphism as well as hemoglobin A1c(HbA1c) were detected, and the bone mineral density (BMD) in lumbar spine (L2 4) was measured. Results: There was no significant difference in the distribution of allele T and C among Group OP, Group T2DM and Group T2DM +OP. The allele frequency distribution on C and T in subjects with OP (Group OP, Group T2DM +OP) and without OP (Group T2DM, Group control) showed significant difference (P 0.015). There were no significant differences in the levels of HbA1c among the different genotypes of CC, CT and TT. Conclusions: TGF β1 509 T allele may be the susceptible gene to OP. The TGF β1 509 genotypes of T2DM patients of had no correlation with HbA1c.
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