网络编辑平台

编辑出版

《中国临床医学》编辑部

  地址:上海市枫林路179号18号楼501室

  邮编:200032

  电话:021-60267570

  邮箱:(1)zglcyx@126.com; (2)zglcyxfb@126.com

作者园地

在线调查

您喜欢的投稿方式调查


相关下载

您所在位置:首页->过刊浏览->第19卷第2期


论著:盐酸戊乙奎醚注射液对乳腺癌全麻术中知晓发生的影响
Effects of Penehyclidine Hydrochloride on the Incidence of Intraoperative Awareness in Patients Undergoing Breast Cancer Surgery During General Anesthesia
王敬 谭志明 朱赟 任瑜 朱敏敏 陈家伟 徐亚军
点击:1175次 下载:0次
作者单位:复旦大学附属肿瘤医院麻醉科
中文关键字:盐酸戊乙奎醚注射液;麻醉;术中;知晓
英文关键字:Penehyclidine hydrochloride;Anesthesia;Intraoperative;Awareness
中文摘要:目的:探讨在全凭静脉麻醉及脑电双频指数监测下静脉注射盐酸戊乙奎醚注射液(penehyclidine hydrochloride,PHC)对乳腺癌手术患者术中知晓发生的影响。方法:400例择期行乳腺癌手术的患者随机分为研究组(n=200)和对照组(n=200),分别于术前30 min静脉注射0.01 mg/kg PHC或等容量的0.9%氯化钠液。采用改良Brice interview问卷调查方式,在术后2~6 h和24~48 h分别进行2次随访,调查并记录患者主诉情况。由对分组不知情的3位麻醉医师分别独立判断是否发生术中知晓,至少有2位同时认定才能确认为术中知晓。结果:研究组术中知晓发生率为0% (0/200),对照组术中知晓发生率为2.5% (5/200),2组差异有统计学意义(P<0.05)。结论:盐酸戊乙奎醚注射液可以减少全麻乳腺癌手术患者术中知晓的发生率。
英文摘要:Objective: To evaluate the effects of penehyclidine hydrochloride (PHC) on the incidence of intraoperative awareness in patients undergoing breast cancer surgery under bispectral index guided total intravenous anesthesia. Methods: A total of 400 patients scheduled for breast cancer surgery were randomly divided into either the PHC group (receiving 0.01 mg/kg PHC intravenously 30 min before surgery) or the saline group (receiving saline intravenously as placebo). Intraoperative awareness was defined as postoperative recall of events occurring during operation. Modified Brice interview was used to assess awareness in the study. Patients were interviewed between 2 h and 6 h postoperatively, as well as between 24 h and 48 h postoperatively. A committee of three experts blinded to the study conditions, independently scrutinized all reported recollections. Confirmed awareness was defined as two or three coding ‘awareness’. Results: None of 200 (0%) and 5 of 200 (2.5%) who received PHC and saline, respectively, were reported awareness about intraoperative events (P<0.05). Conclusions: PHC reduced the incidence of intraoperative awareness in patients undergoing breast cancer surgery during general anesthesia.
读者评论

      读者ID: 密码:   
我要评论:
主办单位:复旦大学附属中山医院
联系地址:上海市枫林路179号18号楼501室 邮编:200032
联系电话:021-60267570 E-Mail:(1)zglcyx@126.com; (2)zglcyxfb@126.com
版权所有©2009-2010 《中国临床医学》杂志编辑部 沪ICP备1103249号
本系统由北京菲斯特诺科技有限公司设计开发
您是本站第1269991名访问者