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论著:还原型谷胱甘肽治疗行机械通气慢性阻塞性肺疾病患者的疗效
Effect of Reduced Glutathione on Mechanical Ventilation Used in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease
张勇刚 李海明 赵兵 张华茹
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作者单位:河南省驻马店市中心医院呼吸内科
中文关键字:还原型谷胱甘肽;慢性阻塞性肺疾病;机械通气
英文关键字:Reduced glutathione; Chronic obstructive pulmonary disease; Mechanical ventilation
中文摘要:目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)患者行机械通气治疗时应用还原型谷胱甘肽的疗效。方法:47例COPD合并呼吸衰竭行机械通气治疗的患者分为对照组(n=25)和治疗组(n=22)。对照组给予抗感染、化痰、平喘、营养支持;治疗组除予上述治疗外,还从上机第1天始每天同时给予静脉滴注还原型谷胱甘肽注射液(1.8 g/d),至顺利撤机或病死,观察2组患者治疗前后的动脉血气变化,观察机械通气时间、住院时间、住重症监护病房(ICU)时间和存活率。结果:2组治疗前后的动脉血气结果无显著差异(P>0.05);治疗组机械通气时间、住院时间、住ICU时间显著少于对照组;2组患者的存活率无显著差异。结论:对进行机械通气的COPD患者应用还原型谷胱甘肽能缩短机械通气时间、缩短住院时间、缩短住ICU的时间。
英文摘要:Objective:To investigate the effect of reduced glutathione on mechanical ventilation used in patients with acute exa cerbations of chronic obstructive pulmonary disease(COPD). Methods: A total of 47 cases of respiratory failure with COPD were divided into treatment group(n=22) and control group (n=25). Both groups were given routine antibiotic,expectorant, draw gasps and nutritional support, 1.8 g/d intravenous reduced glutathione was given to the treatment group until weaning from mechanical ventilation or death. The changes in arterial blood gas before and after treatment, the duration of total mechanical ventilation, duration of hospital stay, intensive care unit (ICU) stay, survival rate were observed. Results: No significant difference was found in the changes in arterial blood gas of these two groups (P>0.05). Compared with treatment group,control group had shorter periods of mechanical ventilation, hospital stay and ICU stay.No significant difference was found in the survival rates of these two groups. Conclusions: Adding reduced glutathione during mechanical ventilation can shorten the duration of ventilation, shorten the length of hospital and ICU stay, decrease the costs in hospital and improve the prognosis rate in COPD.
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