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论著:液基薄层细胞学技术在尿路上皮癌患者术后随访中的应用
Application of Thinprep Cytologic Test in Urothelial Carcinoma Patients’ Following-up after Operation
陈卓 金伟
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作者单位:复旦大学附属金山医院泌尿外科
中文关键字:尿液;液基细胞学;尿路上皮癌;随访
英文关键字:Urine; Thinprep cytologic test; Urothelial carcinoma; Follow-up
中文摘要:目的:探讨尿液膜式液基薄层细胞学技术(TCT)在尿路上皮癌患者术后随访中应用的临床价值。方法:对74例尿路上皮癌患者进行术后随访,定期行尿液TCT和手工涂片法找尿中肿瘤细胞和监测肿瘤复发,并对结果进行分析。结果:在本组74例患者之中,25例高级别尿路上皮癌患者,随访近1年,复发13例,其中尿液TCT找到肿瘤细胞11例,灵敏度84.6%,且有6例患者尿液TCT检查要早于膀胱镜检查发现肿瘤复发;手工涂片法尿中找到肿瘤细胞7例,灵敏度为53.8%。41例低级别尿路上皮癌患者中,随访近1年,复发6例,其中尿液TCT检查找到肿瘤细胞4例,灵敏度66.7%;手工涂片法尿中找到肿瘤细胞2例,灵敏度为33.3%。结论:尿液TCT检查较手工涂片法更为灵敏,可以应用于尿路上皮癌患者术后随访,且对肿瘤复发能起到早发现、早诊断的作用。
英文摘要:Objective: To study the clinical value of Thinprep cytologic test(TCT) in urothelial carcinoma patients’ following-up after operation. Methods: A total of 74 cases of UC were followed up regularly by urine examination of TCT and traditional manual smear method. Urine tumor cells were determined and the tumor recurrence events were monitored. Results: In this group of 74 cases of patients, 25 cases of high grade urothelial carcinoma patients, followed up for one year, recurrence of 13 cases, urine examination of TCT found the tumor cells is 11, the sensitivity rate was 84.6%, and 6 patients with urine examination of TCT earlier than for cystoscopy found tumor recurrence. The urine examination of traditional manual smear method found tumor cells is 7, the sensitivity rate was 53.8%. All the 41 cases of low grade urothelial carcinoma patients were followed up for one year, recurrence events were found in cases. Urine examination of TCT found the tumor cells was 4, the sensitivity rate was 66.7%. The urine examination of traditional manual smear method found the tumor cells was 2, and the sensitivity rate was 33.3%. Conclusions: Urine TCT check more sensitive than manual smear method and can be used in the urothelial carcinoma patients were followed up for tumor recurrence, and can play the early detection and early diagnosis function.
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