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论著:甘油果糖肾上腺素注射液用于内镜下黏膜切除术
Application of Glycerin Fructose and Epinephrine Injection in Endoscopic Mucosal Resection
潘政 张勇军 黄晓俊 张德奎 刘子燕 李艳
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作者单位:兰州大学第二医院消化科
中文关键字:内镜下黏膜切除术;黏膜下注射;甘油果糖;肾上腺素
英文关键字:Endoscopic mucosal resection (EMR);Submucosal injection;Glycerin fructose;Epinephrine
中文摘要:目的:探讨在内镜下黏膜切除术(EMR)中应用甘油果糖0.05%肾上腺素美蓝注射液黏膜下注射的疗效。方法:注射针经内镜于黏膜下层分点注射甘油果糖0.05%肾上腺素美蓝注射液,≤1 cm的病灶注射1~3 mL;>1 cm的病灶周围注射3~5 mL,以病灶明显隆起、黏膜与黏膜下肌层分离为限。圈套器经内镜套取病灶并电凝切除。对较大病灶不能整块套取切除者,采用分次套取摘除。结果:用甘油果糖肾上腺素注射液行EMR术共147例,其中术中钛夹止血6例(4%),无穿孔及大出血。结论:甘油果糖肾上腺素注射液可以明显缩短EMR术时间,并发症发生率较低,可提高EMR疗效和安全性。
英文摘要:Objective: To study the effect of glycerin fructose and epinephrine injection in submucosa in endoscopic mucosal resection (EMR) treatment. Methods: A total of 0.05% glycerin fructose and epinephrine and methylene blue injection were injected into submucosa via injection needle through endoscopy in point injection way, and 1-3ml injections were injected into lesions≤1cm, 3-5ml injections were given to lesions> 1cm,when the lesion was elevated and separative to submucosal muscle layer,the injection should be stoped,then got it by snare wire and resect it by electricity coagulation. For larger lesions that could not be resected entirely could be resected in piecemeal way. Results: Glycerin fructose and epinephrine injection group results. In 147 cases of EMR treatment with glycerin fructose and epinephrine injection, 6 patients(4%) had complication of hemorrhage and suffered hemostatic treatment with titanium clips, no one had perforation and massive hemorrhage. Conclusions: With the advantage of high hypertonic permeability and high-viscosity characteristics, glycerin fructose can significantly shorten operation time, lower rate of complications of EMR treatment and improve the efficacy and safety of EMR.
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