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论著:非小细胞肺癌患者转化生长因子β1水平与机体免疫状态的关系
Relationship between Transforming Growth Factor-Beta1 and Immunologic Functions in Non-Small Cell Lung Carcinoma Patients
雷玉洁 黄云超 陈小波 赵光强 杨凯云 陈颖
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作者单位:昆明医学院第三附属医院胸心外科
中文关键字:转化生长因子β1;非小细胞肺癌;细胞免疫
英文关键字:Transforming growth factor-β1;Non-small cell lung carcinoma;Cellular immunity
中文摘要:目的:探讨非小细胞肺癌(NSCLC)患者外周血中转化生长因子β1(TGF-β1)水平与机体免疫功能变化及与NSCLC分期、病理类型的关系。方法:87例病理证实为 NSCLC并依据2009年国际抗癌联盟和国际肺癌研究会公布的第7版肺癌国际分期法为Ⅰ~Ⅳ期的患者;42例健康人为对照组。应用酶联免疫吸附(ELISA)法检测空腹外周静脉血中TGF-β1含量。采用流式细胞仪检测外周血中CD3+、CD4+、CD8+、CD4+/CD8+和CD4+CD25+细胞比例, 并进行分层分析。结果:NSCLC 患者CD3+、CD4+、CD8+细胞比例显著低于对照组(P<0.01);TGF-β1含量和CD4+CD25+细胞比例显著高于对照组(P<0.01);NSCLCⅠ期和Ⅱ期患者CD3+、CD4+、CD8+细胞比例显著高于Ⅲ期和Ⅳ期患者(P<0.01);而TGF-β1水平和CD4+CD25+细胞比例显著低于Ⅲ期和Ⅳ期患者(P<0.01);但Ⅰ期和Ⅱ期之间、Ⅲ期和Ⅳ期之间差异无统计学意义(P>0.05)。在不同病理类型之间TGF-β1水平和CD3+、CD4+、CD8+、CD4+/CD8+和CD4+CD25+细胞比例均差异无统计学意义(P>0.05)。结论:NSCLC患者外周血中TGF-β1 和CD4+ CD25+水平与患者的免疫功能呈负相关,TNM分期越晚,机体细胞免疫功能越低,TGF-β1水平和CD4+ CD25+细胞比例越高;但TGF-β1含量在NSCLC不同病理类型间差异无统计学意义。
英文摘要:Objective: To investigate the transforming growth factor β1 (TGF-β1) levels and changes of immune function with cancer stage、histological type of cancer in the non-small cell lung carcinoma patients. Methods: A total of 87 hospitalized patients which were histological confirmed non-small cell lung carcinoma (NSCLC), based on the 2009 International Union Against Cancer (UICC) and the International Lung Cancer Research (IASLC) published the seventh edition of the international staging of lung cancer, staging into the group Ⅰ-Ⅳ of patients; also included 42 cases of healthy control subjects. Enzyme-linked immunosorbent assay (ELISA) in peripheral blood fasting TGF-β1 content. Peripheral blood by flow cytometry in CD3+, CD4+, CD8+, CD4+ / CD8+ and CD4+ CD25+ cell percentage, and stratified analysis. Results: NSCLC patients with CD3+, CD4+, CD8+ cells was significantly lower than the controls (P<0.01); TGF-β1 levels and CD4+CD25+ cells was higher (P<0.01); NSCLC patients with stage Ⅰ and Ⅱ CD3+, CD4+, CD8+ cells was higher than in stage Ⅲ and Ⅳ (P<0.01); and TGF-β1 levels and CD4+CD25+ cells was lower than in stage Ⅲ and Ⅳ (P<0.01); but Ⅰ and Ⅱ of room, Ⅲ and Ⅳ was no significant difference between (P> 0.05). Between the different pathological types of TGF-β1 levels and CD3+, CD4+, CD8+, CD4+/CD8+ and CD4+CD25+ cells was not significantly different (P> 0.05). Conclusions: NSCLC patients with the TGF-β1 and CD4+CD25+ levels and the patient's immune function is a negative correlation, TNM stage later, the immune function, the lower, TGF-β1 levels and CD4+CD25+ cells are higher; but TGF -β1 levels in NSCLC are no difference between different pathological types.
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