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论著:小剂量米非司酮治疗子宫肌瘤的疗效观察
The Efficacy and Safety of Low-dose Mifepristone for Uterine Leiomyomas
卞政 姚霞琴
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作者单位:上海市第一妇婴保健院浦东分部
中文关键字:米非司酮;子宫肌瘤;子宫内膜
英文关键字:Mifepristone; Uterine leiomyomas; Endometrium
中文摘要:目的:观察长期小剂量米非司酮治疗子宫肌瘤的疗效及对性激素和子宫内膜的影响。方法:子宫肌瘤的患者100例,月经第3~5天开始服用米非司酮共6.5个月。随访症状、体征、B超检查结果及不良反应,监测血性激素水平,血红蛋白以及用药后子宫内膜情况。结果:所有患者均出现闭经,症状和体征得到不同程度改善,用药6.5个月孕激素及雌二醇水平比用药前显著降低(P<0.01),停药3个月恢复至用药前水平;卵泡刺激素及黄体生成素水平则无明显变化。血红蛋白较前有明显升高。用药后子宫内膜病理证实无异常的表现。结论:米非司酮治疗子宫肌瘤疗效明显且安全。
英文摘要:Objective: To assess long-term effects of low-dose mifepristone on leiomyoma regression, symptoms, hormones, and endometrial pathology.Methods: A total of 100 randomized women with large, symptomatic leiomyomas were controlled to take oral mifepristone in the period for 6.5 months. We followed up the symptom, side-effect, ultrasound, hormone levels and endometrium.Results: The symptoms of all cases were ameliorated. Progesterone and estradiol were obviously decreased (P<0.01) and rebounded to original level 3 months later since stopping the mifepristone. FSH and LH were no change. Haemoglobin was increased than before. Although some cases had little side-effect, there was no abnormal endometrial pathology change in long-term and low-dose treatment. Conclusion:It was indicated that the long-term and low-dose mifepristone treatment in leiomyoma was safe, efficient and no obvious change in hormone.
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